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ן»¿Product info: Allergy
Periactin (CYPROHEPTADINE) is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Cyproheptadine useful in conditions such as vascular headache and anorexia. Cyproheptadine does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Cyproheptadine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Cyproheptadine exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Cyproheptadine's antiemetic effects, although the exact mechanism is unknown. Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadine's ability to stimulate appetite. Cyproheptadine also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Cyproheptadine exerts a beneficial effect on this condition. For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.

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ן»¿Cyproheptadine Hydrochloride
Pronunciation: (sip-row-HEP-tuh-deen HIGH-droe-KLOR-ide)
Class: Piperidine, nonselective

Trade Names:
Cyproheptadine Hydrochloride
- Tablets 4 mg
- Syrup 2 mg per 5 mL
Pharmacology
User Reviews & RatingsAs a treatment for... Avg User Ratings [?]
Hay Fever
1 reviews Rate it! 10
Cluster Headaches
1 reviews Rate it! 9.0
Pruritus
0 reviews Rate it! 9.0

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Competitively antagonizes histamine at H 1 receptor sites. Also exhibits antiserotonin activity.
Pharmacokinetics
Metabolism

The principal metabolite found in the urine is the quaternary ammonium glucuronide conjugate of cyproheptadine.
Elimination

2% to 20% is excreted in the feces, of which 34% (5.7% of the dose) is unchanged drug. At least 40% is excreted in the urine.
Indications and Usage

Symptomatic relief of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis; amelioration of allergic reactions to blood or plasma; management of allergic pruritic symptoms, mild skin manifestations of uncomplicated urticaria and angioedema, and cold urticaria; dermographism; adjunctive anaphylactic therapy.
Unlabeled Uses

Prophylactic treatment of pediatric migraines; suppression of vascular headaches; appetite stimulation.
Contraindications

Hypersensitivity to antihistamines; newborn or premature infants; breast-feeding mothers; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; bladder neck obstruction; pyloroduodenal obstruction; elderly, debilitated patients; MAO therapy.
Dosage and Administration
Adults

PO Starting dose, 4 mg every 8 h. Usual dose, 4 to 20 mg/day; not to exceed 0.5 mg/kg/day.
Children 7 to 14 yr of age

PO 4 mg bid or three times daily (max, 16 mg/day).
Children 2 to 6 yr of age

PO 2 mg 2 or 3 times daily (max, 12 mg/day). ( PO Total daily dosage 0.25 mg/kg or 8 mg/m 2 .)
General Advice
Administer without regard to meals. Administer with food if GI upset occurs.
Measure and administer prescribed dose of syrup using dosing syringe, dosing spoon, or dosing cup.
Storage/Stability

Store tablets and syrup at controlled room temperature (59ֲ° to 86ֲ°F). Keep container tightly closed.


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Periactin

Cyproheptadine

Periactin - Includes detailed dosage instructions.

Cyproheptadine
Compare Periactin with other medications for the treatment of:

Hay Fever, Migraine, Cluster Headaches, Pruritus, Allergic Reactions, Anorexia, Anorexia Nervosa, Sexual Dysfunction, SSRI Induced, Cushing's Syndrome, Urticaria
User reviews

5 review(s) for Periactin
Support Group Questions & Answers
Periactin - do they normally prescribe to children under18 who have migranes and absent siezures?
If I did a drug test while taking this will I fail it periactin?
Can periactin increase your appetite?

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